Modulation of Electroosmotic Flow through Skin: Effect of Poly(Amidoamine) Dendrimers

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Modulation of Electroosmotic Flow through Skin: Effect of Poly(Amidoamine) Dendrimers

The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied, using generation 1, 4 and 7 dendrimer (G1, G4 and G7, respectively). As a marker molecule for the direction and magnitude of EOF, a neutral molecule, acetoaminophen (AAP) was used. The visualization of...

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Polyamidoamine (PAMAM) dendrimers are multi-branched, three-dimensional polymers with unique architecture, which makes these molecules attractive for medical and pharmaceutical applications. Using PAMAM as drug carriers for topical delivery might be beneficial as they only produce a transient effect without skin irritation. To evaluate the dermal toxicity of cationic PAMAM dendrimers generation...

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ژورنال

عنوان ژورنال: Biomolecules & Therapeutics

سال: 2018

ISSN: 2005-4483,1976-9148

DOI: 10.4062/biomolther.2017.203